How to Diagnose Celiac Disease
Celiac disease, also known as gluten-sensitive enteropathy, is prevalent but often overlooked. It is an autoimmune disease of intestinal damage from gluten in genetically predisposed individuals. They vary in severity. Some are very sensitive, i.e., they are favorable in milder forms of the disease, but are non-specific, i.e., a fair assessment may not indicate coeliac disease. Others are considered quite definitive, meaning that you almost certainly have the disease if they are positive. You can read this article to know more.
Immunoglobulin Test
These tests are IgA-based and can be harmful if you are deficient in IgA immunoglobulin, which occurs in 10-20 percent of people with celiac disease. If EMA or tTG is positive, coeliac disease is very likely, and an intestinal biopsy is usually appropriate. Recent studies show that tTG may be positive in only 40% of actual coeliac disease cases if the biopsy shows a moderate degree of intestinal damage. They may also be more accurate than EMA and tTG antibody tests, but they are not yet widely available.
Blood Test
The exact painful problem for people with minor gluten intolerance who have borderline or regular blood tests or biopsies yet respond to a gluten-free diet plan is that they are not taken seriously or do not understand for sure they are gluten-allergic. These stool tests have been performed in research laboratories and published in two or three studies for all these people, but only recently have they become available through Enterolab, an industrial laboratory.
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